Trifexis Heartworm/Flea&Tic meds may have fatal side effects - Golden Retrievers : Golden Retriever Dog Forums
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post #1 of 25 (permalink) Old 12-09-2011, 08:23 PM Thread Starter
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Trifexis Heartworm/Flea&Tic meds may have fatal side effects

I am reposting this from an Old Chatevo Lab board Member. She just had to send her beloved yellow lab Iris to the Bridge. The Heartworm/Flea&Tic med "may possibly" be the cause of Ivy's illness. I will be posting on Facebook what Pam finds and I will post it here to keep everyone abreast of what is going on.

Ivy Monahan - from Pam Monahan: Iris suddenly became very ill last week with intestinal issues. She was treated twice at our regular vet; once for diarrhea and then for vomiting, lethargy, not eating. Her lab results came back normal except for her thyroid, which was very low. She started medication for low thyroid, but then starting vomiting. She had been at the emergency vet for two days of tests. She had many tests performed there, including 2 ultra sounds and a barium swallow. They could find nothing wrong; no blockage, no foreign object, nothing. She lost 6 pounds in a week. She worsened overnight and when we visited with her this morning we made the decision to let her go and were with her when she passed. We had given Iris and Ivy a dose of Trifexis, a heart-worm preventative/flea control medication on November 29 and Iris became ill the next day. That is when we took her to our vet. So, a week and a day later, a dog that was fine and loving life, is gone. The ER Vet initially was skeptical of my concern about this heart-worm preventative medication, but did immediately perform a necropsy, at our request. She saw no evidence of advanced cancer, but did send off tissue samples for analysis. And, she herself contacted the manufacturer of Trifexis and Iris has a case number. It certainly would have been easier if she had been eaten up with cancer or even swallowed something. So, now we are involved with a pharmaceutical company, Elanco (Eli Lilly). Just want to ensure that this does not happen to other dogs.
We are broken hearted. I reposted this so everyone can read it and be aware of this. I will keep you posted on what they find out.

John,Becky,Pearl,&Cricket...Millie & Brandy at the BRIDGE
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post #2 of 25 (permalink) Old 12-10-2011, 09:14 AM Thread Starter
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Another "possible" Trifexis poisoning.

This is from the Labrador Retriever Forum...

Trifexis problems with our dog too.... BEWARE OF TRIFEXIS!





This is not related to a Labrador but is related to Trifexis. The day before Thanksgiving Wednesday we took our healthy 3.5 year old male Dacshaund to the vet. He had a normal checkup and we received a 6 pack of Trifexis. On Thanksgiving morning we gave him a dose of Trifexis. Within 3 hours he became very ill including problems with balance, stiff neck, lethargic, and really just sick. This progressed over several days and we took him to the vet again. We were then referred to a surgeon as his problems were thought to be orthopedic. The surgeon after 5 days and many tests (over $2k) he is being diagnosed with GME. This dog was very healthy and active before taking Trifexis. He is still very ill and can not walk very well. The prognosis is poor and the vet says will eventually result in death.

WE are devastated.

I think it is too much of a co-incidence that he became ill within 3 hours of taking this medication and the onset of this disease. I would NOT give my dog Trifexis if I were you!

John,Becky,Pearl,&Cricket...Millie & Brandy at the BRIDGE
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post #3 of 25 (permalink) Old 12-10-2011, 03:45 PM
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I don't want to make light of these side effects but with every drug there will be possible side effects. Many pets have reactions to vax as well as topical flea meds.

We've been using Trifexis for several months now with no problems. After giving Hank his first and dose I watched him very carefully to make sure he was tolerating the drug well. Even now I keep him indoors to make sure he doesn't vomit-up the pill in our wooded yard where I wouldn't know it, thus loosing the effects of the heartworm preventative.

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post #4 of 25 (permalink) Old 06-05-2013, 05:42 AM
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Trifexis may have given my 3-year-old Golden cancer also

We needed to put down our incredibly healthy, funny and loving Golden on Monday, June 3, 2013. Coincidentally, he also began Trifexis and was given his 2nd dosage less than a week before he got sick. Thowing up and not eating. This was a large, healthy dog. He fought valiantly. I didn't know what to think. I mentioned the new heartworm/flea meds to the vet when we brought Charlie in but she didn't reply to that one.

A dog, otherwise healthy, suddenly becomes listly, throwing up and developing an autoimmune disease that kills him? I am crazy about this one.
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post #5 of 25 (permalink) Old 06-05-2013, 09:38 AM
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Above poster: I am so sorry for the loss of your fur baby, and being so young, that is terrible.
I really don't believe that the cancer had something to do with the Trifexis. He must have had the cancer in his system before you started the first dose of Trifexis.
Did your dog die of hemangiosarcoma? That is a fast moving incurable cancer that occurs so often in goldens. My fur baby died of it without much warning about 9 weeks ago.
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post #6 of 25 (permalink) Old 06-05-2013, 11:51 AM
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Quote:
Originally Posted by cgriffin View Post
Above poster: I am so sorry for the loss of your fur baby, and being so young, that is terrible.
I really don't believe that the cancer had something to do with the Trifexis. He must have had the cancer in his system before you started the first dose of Trifexis.
Did your dog die of hemangiosarcoma? That is a fast moving incurable cancer that occurs so often in goldens. My fur baby died of it without much warning about 9 weeks ago.
The OP said an auto immune disease, not cancer. As an owner of a dog that reacted terribly to Comfortis, I can certainly believe Trifexis might preciptate an auto immune disease.

To the OP, I am so sorry for your loss.

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post #7 of 25 (permalink) Old 06-05-2013, 11:56 AM
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Originally Posted by Dallas Gold View Post
The OP said an auto immune disease, not cancer.

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On another thread I think they said their dog passed away from cancer.

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post #8 of 25 (permalink) Old 06-05-2013, 12:05 PM
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On another thread I think they said their dog passed away from cancer.
Thanks, did not see that thread. I doubt the med would cause cancer so fast.

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post #9 of 25 (permalink) Old 06-05-2013, 01:06 PM
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Quote:
Originally Posted by Dallas Gold View Post
The OP said an auto immune disease, not cancer. As an owner of a dog that reacted terribly to Comfortis, I can certainly believe Trifexis might preciptate an auto immune disease.

To the OP, I am so sorry for your loss.

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The OP said cancer in the thread 'lead-in' statement (in bold) then said within the thread an auto immune disease.

ETA: Not the OP but the Poster that reserrected the threadl.

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Last edited by Willow52; 06-05-2013 at 01:42 PM.
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post #10 of 25 (permalink) Old 06-05-2013, 01:21 PM
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Exactly, sounds a bit misleading and confusing.
All I am saying is, that I don't think that within the time frame she is stating, that cancer can develop and kill that quickly, even if it was Hemangio which we don't know. First dose of Trifexis dog is fine, few days after second dose dog diagnosed with cancer and dies, sounds like about a 5 week time frame and way too fast.
So, I am assuming the cancer was in the system prior to the first dose of Trifexis and it is possible that the Trifexis made matters worse if the dog was already immune compromised.
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