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Trifexis has Comfortis in it, which is a flea pill.
I have never used Trifexis but I used Comfortis till last month. I usually use it over the winter months. My vet had told me that it is said to have a mild tick action, but he has no evidence of it. Well, it does have a mild tick action. For about three weeks, I found dead ticks on my dogs this past month before I started back up with Frontline Plus for ticks. We have a huge tick problem here in the South. If you are in a low tick area, Trifexis may just be enough for both fleas and ticks.